Cat. No. 4107

Probenecid C13H19NO4S [57-66-9]

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Chemical Name: 4-(Dipropylsulfamoyl)benzoic acid

Biological Activity

Inhibitor of multidrug resistance-associated proteins (MRP). Inhibits organic acid transport in the kidney and other organs. Also exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM).

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Cunningham et al (1981) Clinical pharmacokinetics of probenecid. Clin.Pharmacokinet. 6 135. PMID: 7011657.

Hammond et al (2007) Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J.Biol.Chem. 282 14337. PMID: 17374608.

Silverman et al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am.J.Physiol.Cell Physiol. 295 C761. PMID: 18596212.

Ishikawa et al (2010) Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol.Pharm.Bull. 33 504. PMID: 20190417.

If you know of a relevant citation for this product please let us know.

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Keywords: Probenecid, supplier, ATP-binding, cassette, ABC, multidrug, resistance-associated, proteins, MRP, inhibitors, Multidrug Transporter Inhibitors

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