Cat. No. 4100
Chemical Name: 2-Methyl-1-[3-(4-morpholinyl)propyl
Biological ActivityPotent and selective TRPV4 antagonist. Reversibly inhibits currents through mouse, human and rat TRPV4 orthologs (IC50 values are 17, 48 and 133 nM respectively). Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Everaerts et al (2010) Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc.Natl.Acad.Sci. 107 19084.
If you know of a relevant citation for this product please let us know.
View Related Products by Product Action
Keywords: HC 067047, supplier, HC067047, trpv4, transient, receptor, potential, channels, potent, selective, antagonists, TRPV Antagonists
Find multiple products by catalog number
New Products in this Area
Potent and selective TRPV1 antagonistCIM 0216
Selective TRPM3 agonistMRS 1477
TRPV1 positive allosteric modulatorMK6-83
TRPML channel activator
December 15 - 17, 2015