Cat. No. 4100
Chemical Name: 2-Methyl-1-[3-(4-morpholinyl)propyl
Biological ActivityPotent and selective TRPV4 antagonist. Reversibly inhibits currents through mouse, human and rat TRPV4 orthologs (IC50 values are 17, 48 and 133 nM respectively). Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Everaerts et al (2010) Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc.Natl.Acad.Sci. 107 19084.
If you know of a relevant citation for this product please let us know.
Keywords: HC 067047, supplier, HC067047, trpv4, transient, receptor, potential, channels, potent, selective, antagonists
Find multiple products by catalog number
New Products in this Area
Potent and selective TRPM8 antagonist; orally activeM8 B hydrochloride
Potent and selective TRPM8 channel blockerClemizole hydrochloride
TRPC5 blocker; also H1 antagonist
April 13 - 15, 2015