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Amiodarone hydrochlorideCat. No. 4095 |
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Chemical Name: 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride |
Biological Activity
Broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.Certificate of Analysis / Safety Data Sheet
References
di Matola et al (2000) Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism. J.Clin.Endocrin.Metab. 85 4323. PMID: 11095475.
Antzelevitch et al (2004) Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110 904. PMID: 15302796.
Zhang and Rao (2007) Global disruption of cell cycle progression and nutrient response by the antifungal agent amiodarone. J.Biol.Chem. 282 52.
Balgi et al (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4 e7124. PMID: 19771169.
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Keywords: Amiodarone hydrochloride, supplier, ion, channels, antagonists, blockers, INa, ICa, IKr, IKs, antiarrhythmic, class, III
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