Puromycin dihydrochloride

Cat. No. 4089

Puromycin dihydrochloride C22H29N7O5.2HCl [58-58-2]

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Chemical Name: 3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride

Biological Activity

Protein synthesis inhibitor; leads to the premature release of polypeptide chains as polypeptidyl purine derivatives. Analog of the 3' end of aminoacyl-tRNA. Aminonucleoside antibiotic. Inhibits translation in both in vitro and in vivo systems. Also inhibits the transport of proteins into the mitochondria in vitro.

Technical Data

M.Wt:
544.43
Formula:
C22H29N7O5.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
58-58-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Azzam and Algranati (1973) Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes. Proc.Nat.Acad.Sci. 70 3866.

Price and Verner (1993) Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction. Biochim.Biophys.Acta. 1150 89. PMID: 8334141.

If you know of a relevant citation for this product please let us know.

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Keywords: Puromycin dihydrochloride, supplier, Puromycin, antibiotics, protein, synthesis, inhibitors, inhibits, translation, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitors

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