R&D Systems Inc. Tocris Bioscience Boston Biochem

PS 48

Cat. No. 4087

PS 48 C17H15ClO2 [1180676-32-7]

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Chemical Name: (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic acid

Biological Activity

Phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.

Technical Data

M.Wt:
286.75
Formula:
C17H15ClO2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1180676-32-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Hindie et al (2009) Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat.Chem.Biol. 5 758. PMID: 19718043.

Stroba et al (2009) 3,5-diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J.Med.Chem. 52 4683. PMID: 19606904.

Williams (2010) Elastic network model of allosteric regulation in protein kinase PDK1. BMC Struct.Biol. 10 11. PMID: 20500829.

Zhu et al (2010) Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell. 7 651. PMID: 21112560.

If you know of a relevant citation for this product please let us know.

Keywords: PS 48, supplier, phosphoinositide-dependent, protein, kinase, 1, pdk1, activators, allosteric, PS48

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