Cat. No. 4087
Chemical Name: (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-
Biological ActivityPhosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Hindie et al (2009) Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat.Chem.Biol. 5 758. PMID: 19718043.
Stroba et al (2009) 3,5-diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J.Med.Chem. 52 4683. PMID: 19606904.
Williams (2010) Elastic network model of allosteric regulation in protein kinase PDK1. BMC Struct.Biol. 10 11. PMID: 20500829.
Zhu et al (2010) Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell. 7 651. PMID: 21112560.
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Keywords: PS 48, supplier, phosphoinositide-dependent, protein, kinase, 1, pdk1, activators, allosteric, PS48
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