PS 48

Cat. No. 4087

PS 48 C17H15ClO2 [1180676-32-7]

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Chemical Name: (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic acid

Biological Activity

Phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.

Technical Data

M.Wt:
286.75
Formula:
C17H15ClO2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1180676-32-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Hindie et al (2009) Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat.Chem.Biol. 5 758. PMID: 19718043.

Stroba et al (2009) 3,5-diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J.Med.Chem. 52 4683. PMID: 19606904.

Williams (2010) Elastic network model of allosteric regulation in protein kinase PDK1. BMC Struct.Biol. 10 11. PMID: 20500829.

Zhu et al (2010) Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell. 7 651. PMID: 21112560.

If you know of a relevant citation for this product please let us know.

Keywords: PS 48, supplier, phosphoinositide-dependent, protein, kinase, 1, pdk1, activators, allosteric, PS48

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