Niclosamide

Cat. No. 4079

Niclosamide C13H8Cl2N2O4 [50-65-7]

Price and Availability

For Niclosamide pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

Biological Activity

Inhibitor of the STAT3 signaling pathway; inhibits the activation, nuclear translocation and transactivation of STAT3. Displays selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases. Inhibits the transcription of STAT3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.

Technical Data

M.Wt:
325.99
Formula:
C13H8Cl2N2O4
Solubility:
Soluble to 25 mM in ethanol and to 10 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
50-65-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Balgi et al (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4 e7124. PMID: 19771169.

Jin et al (2010) Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-κB pathway and generation of reactive oxygen species. Cancer Res. 70 2516. PMID: 20215516.

Ren et al (2010) Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signaling pathway. ACS Med.Chem.Lett. 1 454.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: Niclosamide, supplier, STAT3, mTORC1, signaling, signalling, pathway, inhibitors, anthelmintic, Tocris Bioscience, STAT Inhibitors

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

JAK-STAT Pathway

JAK-STAT Signaling Pathway

JAK-STAT signaling is involved in many fundamental cellular processes such as cell proliferation and hematopoiesis. View pathway or download PDF today.

divider line

New Products in this Area

Napabucasin

STAT3 inhibitor; blocks cancer stem cell self-renewal

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.