Cat. No. 4079

Niclosamide C13H8Cl2N2O4 [50-65-7]

Price and Availability

For Niclosamide pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

Biological Activity

Inhibitor of the STAT3 signaling pathway; inhibits the activation, nuclear translocation and transactivation of STAT3. Displays selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases. Inhibits the transcription of STAT3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.

Technical Data

Soluble to 25 mM in ethanol and to 10 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Balgi et al (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4 e7124. PMID: 19771169.

Jin et al (2010) Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-κB pathway and generation of reactive oxygen species. Cancer Res. 70 2516. PMID: 20215516.

Ren et al (2010) Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signaling pathway. ACS Med.Chem.Lett. 1 454.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: Niclosamide, supplier, STAT3, mTORC1, signaling, signalling, pathway, inhibitors, anthelmintic, STAT Inhibitors

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Guide

Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Immunology Guide


Highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

New Products in this Area


Stat3 inhibitor; blocks cancer stem cell self-renewal


mSTING agonist; induces antitumor immunological responses

C 87

TNF-α inhibitor

JTE 607 dihydrochloride

Cytokine release inhibitor; anti-inflammatory

Sign-up for new product e-alerts
divider line

Bio-Techne Events

ASCB 2015

ASCB 2015

December 12 - 16, 2015

San Diego, CA