R&D Systems Inc. Tocris Bioscience Boston Biochem

Fluorobexarotene

Cat. No. 4064

Fluorobexarotene C24H27FO2 [1190848-23-7]

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Chemical Name: 2-Fluoro-4-[1-(5-,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

Biological Activity

RXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors). Displays similar RAR agonist activity to bexarotene; exhibits an apparent RXR binding affinity 75% greater than bexarotene.

Licensing Information

Manufactured and sold under license from Arizona State University - Patent Pending

Technical Data

M.Wt:
366.47
Formula:
C24H27FO2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
1190848-23-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Wagner et al (2009) Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J.Med.Chem. 52 5950. PMID: 19791803.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Fluorobexarotene, supplier, Fluorobexarotene, retinoid, x, rexinoids, rxr, agonists

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