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Fluorobexarotene

Cat. No. 4064

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Chemical Name: 2-Fluoro-4-[1-(5-,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

Biological Activity

RXR agonist (K_i = 12 nM; EC₅₀ = 43 nM at RXRα receptors). Displays similar RAR agonist activity to bexarotene; exhibits an apparent RXR binding affinity 75% greater than bexarotene.

Licensing Information

Manufactured and sold under license from Arizona State University - Patent Pending

Technical Data

M.Wt:

366.47

Formula:

C₂₄H₂₇FO₂

Solubility:

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Purity:

>97 %

Storage:

Store at +4°C

CAS No:

1190848-23-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Wagner et al (2009) Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J.Med.Chem. 52 5950. PMID: 19791803.

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