Cat. No. 4048
Alternative Name: Biphenyl-indanone A
Chemical Name: 3'-[[(2-Cyclopentyl-2,3-dihydro-6,7-
Biological ActivitySelective positive allosteric modulator of mGlu2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2). Displays no effect on glutamate-induced activation of other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bonnefous et al (2005) Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor. Bioorg.Med.Chem.Lett. 15 4354. PMID: 16046122.
Galici et al (2006) Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J.Pharmacol.Exp.Ther. 318 173. PMID: 16608916.
Benneyworth et al (2007) A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. Mol.Pharmacol. 72 477. PMID: 17526600.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BINA, supplier, pam, positive, allosteric, modulators, metabotropic, glutamate, receptors, mglu2, group, II, selective, biphenyl-indanone, A, Glutamate (Metabotropic) Group II Receptor Modulators
Find multiple products by catalog number
New Products in this Area
Potent and selective negative allosteric modulator at mGlu5ABP 688
High affinity human mGlu5 receptor antagonistVU 0469650 hydrochloride
Potent and selective negative allosteric modulator of mGlu1VU 0422288
Selective group III mGlu positive allosteric modulator
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.