Cat. No. 4034
Biological ActivityPeptide that reverses the anticoagulant effect of heparin (Cat. No. 2812). Potently binds heparin (Kd = 36 nM in vitro).
Licensing InformationSold under license
(Modifications: Ala-1 = N-terminal Ac, Ala-19 = ε-Ac, X-36 = Dpr, Ala-37 = β-Ac, Glu-53 = C-terminal Amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Shenoy et al (1999) Development of heparin antagonists with focused biological activity. Curr.Pharmaceut.Des. 5 965.
Schick et al (2004) Novel concatameric heparin-binding peptides reverse heparin and low-molecular-weight heparin anticoagulant activities in patient plasma in vitro and in rats in vivo. Blood 103 4.
Cushing et al (2010) Reversal of heparin-induced increases in aPTT in the rat by PM102, a novel heparin antagonist. Eur.J.Pharmacol. 635 165. PMID: 20307530.
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Keywords: PM 102, supplier, PM102, heparin, antagonists, anticoagulants, HepArrest
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October 15, 2013