R&D Systems Inc. Tocris Bioscience Boston Biochem

PF 4708671

Cat. No. 4032

PF 4708671 C19H21F3N6 [1255517-76-0]

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Chemical Name: 2-[[4-(5-Ethylpyrimidin-4-yl)pipera­zin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]im­idazole

Biological Activity

Cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki = 20 nM; IC50 = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo. Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
390.41
Formula:
C19H21F3N6
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
1255517-76-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Pearce et al (2010) Characterisation of PF-4708671 a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem.J. 431 245. PMID: 20704563.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Kinases
RSK

Keywords: PF 4708671, supplier, PF4708671, selective, inhibitor, inhibitors, p70, ribosomal, S6, kinase, S6K1, inhibits, cancer, Pfizer

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