Cat. No. 4023
Biological ActivityPotent and selective NaV1.7 channel blocker (IC50 = 0.3 nM). Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
(Modifications: Disulfide bridge: 2-16, 9-21, 15-25)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Smith et al (2007) Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation. J.Biol.Chem. 282 12687. PMID: 17339321.
Edgerton et al (2008) Evidence for multiple effects of ProTxII on activation gating in NaV 1.5. Toxicon. 52 489. PMID: 18657562.
Schmalhofer et al (2008) ProTx-II, a selective inhibitor of NaV 1.7 sodium channels, blocks action potential propagation in nociceptors. Mol.Pharmacol. 74 1476. PMID: 18728100.
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Keywords: ProTx II, supplier, toxins, voltage, gated, sodium, Na+, channels, NaV1.7, potent, selective, blockers