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JNJ 5207787

Cat. No. 4018

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Chemical Name: (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide

Biological Activity

Selective NPY Y₂ antagonist (IC₅₀ = 0.1 μM). Displays 100-fold selectivity over NPY Y₁, Y₄ and Y₅ receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant.

Licensing Information

Sold with the permission of Janssen Pharmaceutica N.V.

Technical Data

M.Wt:

510.67

Formula:

C₃₂H₃₈N₄O₂

Solubility:

Soluble to 10 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming

Purity:

>98 %

Storage:

Store at RT

CAS No:

683746-68-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Bonaventure et al (2004) Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y₂ receptor. J.Pharmacol.Exp.Ther. 308 1130. PMID: 14617685.

Jablonowski et al (2004) Novel non-peptide neuropeptide Y Y₂ receptor antagonists. Bioorg.Med.Chem.Lett. 14 1239. PMID: 14980673.

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