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IDE 2Cat. No. 4016 |
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Chemical Name: Heptanedioic acid-1-(2-cyclopentylidenehydrazide) |
Biological Activity
Cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 223 nM for induction of Sox17 expression in ESCs). Reported to activate TGF-β signaling and downstream Smad2 phosphorylation; upregulates Nodal expression. Promotes pancreatic progenitor cell formation in vitro, and gut tube formation in vivo.Licensing Information
Sold for research purpose under license from Harvard University.Certificate of Analysis / Safety Data Sheet
References
Borowniak et al (2009) Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4 348. PMID: 19341624.
Zaret (2009) Using small molecules to great effect in stem cell differentiation. Cell Stem Cell 4 373. PMID: 19427285.
Filby et al (2011) Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells. Stem Cell Res.Ther. 2 16. PMID: 21463501.
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Keywords: IDE 2, supplier, IDE2, inducer, induces, endodermal, formation, embryonic, stem, cells, differentiation, ESCs, nodal, sox17
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