R&D Systems Inc. Tocris Bioscience Boston Biochem

FIIN 1 hydrochloride

Cat. No. 4002

FIIN 1 hydrochloride C32H39Cl2N7O4 [1256152-35-8]

Price and Availability

For FIIN 1 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide

Biological Activity

Potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044).

Technical Data

M.Wt:
693.06
Formula:
C32H39Cl2N7O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>96 %
Storage:
Store at -20°C
CAS No:
1256152-35-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Zhou (2010) A structure-guided approach to creating covalent FGFR inhibitors. Chem.Biol. 17 285. PMID: 20338520.

If you know of a relevant citation for this product please let us know.

Keywords: FIIN 1 hydrochloride, supplier, FIIN1, hydrochloride, FGFR, fibroblast, growth, factors, receptors, irreversible, inhibits, inhibitors, PD173074, FGFR1, FGFR2, FGFR3, FGFR4, Flt-1, Flt-4, VEGFR2

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 400 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Stem Cells Review

5-HT Review

Written by Victoria B. Christie and Stefan A. Przyborski. View PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.

divider line

New Product Guide

NPG

Highlights 150 new products added in the second half of 2014. View PDF today.

divider line

New Products in this Area

NBI 31772

High affinity insulin-like growth factor-I binding protein IGFBP inhibitor

APcK 110

KIT inhibitor

Norleual

Highly potent HGF/c-MET inhibitor; also AT4 antagonist

AEE 788

Potent EGFR and VEGFR inhibitor

XL 184

Potent VEGFR inhibitor; also inhibits other RTKs

PKI 166 hydrochloride

Potent EGFR-kinase inhibitor

ASP 3026

Potent anaplastic lymphoma kinase (ALK) inhibitor

KYL

EphA4 receptor tyrosine kinase inhibitor; neuroprotective

PD 90780

Inhibits NGF binding to p75NTR

Sign-up for new product e-alerts
divider line

Bio-Techne Events

DPG 2015

BNA 2015: Festival of Neuroscience

April 12 - 15, 2015

Edinburgh, UK

Booth: 25A