R&D Systems Inc. Tocris Bioscience Boston Biochem

FIIN 1 hydrochloride

Cat. No. 4002

FIIN 1 hydrochloride C32H39Cl2N7O4 [1256152-35-8]

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Chemical Name: N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide

Biological Activity

Potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044).

Technical Data

M.Wt:
693.06
Formula:
C32H39Cl2N7O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>96 %
Storage:
Store at -20°C
CAS No:
1256152-35-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Zhou (2010) A structure-guided approach to creating covalent FGFR inhibitors. Chem.Biol. 17 285. PMID: 20338520.

If you know of a relevant citation for this product please let us know.

Keywords: FIIN 1 hydrochloride, supplier, FIIN1, hydrochloride, FGFR, fibroblast, growth, factors, receptors, irreversible, inhibits, inhibitors, PD173074, FGFR1, FGFR2, FGFR3, FGFR4, Flt-1, Flt-4, VEGFR2

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