R&D Systems Inc. Tocris Bioscience Boston Biochem

LDN 57444

Cat. No. 3998

LDN 57444 C17H11Cl3N2O3 [668467-91-2]

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Chemical Name: 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)

Biological Activity

Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (Ki = 0.4 μM). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo.

Technical Data

M.Wt:
397.64
Formula:
C17H11Cl3N2O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
668467-91-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837. PMID: 14522054.

Tan et al (2008) Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol.Cell.Biochem. 318 109. PMID: 18622688.

Cartier et al (2009) Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J.Neurosci. 29 7857. PMID: 19535597.

If you know of a relevant citation for this product please let us know.

Keywords: LDN 57444, supplier, LDN57444, UCH, L1, inhibitors, inhibits, ubiquitin, C-terminal, hydrolases, UCH-L1

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