Cat. No. 3966
Chemical Name: N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
Biological ActivitySelective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
Licensing InformationSold with the permission of AstraZeneca UK Ltd.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Bhat and Budd (2002) GSK3α signalling: casting a wide net in Alzheimer's disease. Neurosignals 11 251. PMID: 12566926.
Bhat et al (2003) Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J.Biol.Chem. 278 45937. PMID: 12928438.
Gould et al (2004) AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int.J.Neuropsychopharmacol. 7 387. PMID: 15315719.
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Keywords: AR-A 014418, supplier, ARA014418, glycogen, synthase, kinase, 3, GSK-3, GSK3, inhibitors
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