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Colivelin

Cat. No. 3945

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Biological Activity

Neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.

Technical Data

M.Wt:

2645.13

Formula:

C₁₁₉H₂₀₆N₃₂O₃₅

Sequence:

SALLRSIPAPAGASRLLLLTGEIDLP

Solubility:

Soluble to 1 mg/ml in 30% acetonitrile / water

Storage:

Store at -20°C

CAS No:

867021-83-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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References

Chiba et al (2005) Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo. J.Neurosci. 25 10252. PMID: 16267233.

Yamada et al (2008) Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology 33 2020. PMID: 17928813.

Sari et al (2009) A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. Neuroscience 164 1653. PMID: 19782727.

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