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ANR 94Cat. No. 3937 |
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Chemical Name: 8-Ethoxy-9-ethyl-9H-purin-6-amine |
Biological Activity
Adenosine A2A receptor (AA2AR) antagonist (Ki values are 643 and 46 nM for rat and human AA2ARs respectively). Most active AA2AR antagonist for human receptors. Displays activity in the treatment of Parkinson's disease in vivo; improves parkinsonian motor deficits and tremors. Exhibits neuroprotective and anti-inflammatory effects.Certificate of Analysis / Safety Data Sheet
References
Pinna et al (2010) A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug. Neuropharmacology 58 613. PMID: 19951715.
Volpini et al (2010) Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease. Chem.Med.Chem. 4 1010.
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Keywords: ANR 94, supplier, ANR94, adenosine, A2A, receptor, antagonist, AA2AR, antagonists, antiparkinsonian, activity
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