SJ 172550

Cat No. 3929new product

SJ 172550 C22H21ClN2O5 [431979-47-4]

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Chemical Name: 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H- pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]acetic acid methyl ester

Biological Activity

MDMX inhibitor. Reversibly binds MDMX and inhibits the MDMX-p53 interaction in cultured cells; frees p53 to induce apoptosis.

Technical Data

M.Wt:
428.87
Formula:
C22H21ClN2O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
[431979-47-4]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Reed et al (2010) Identification and characterization of the first small molecule inhibitor of MDMX. J.Biol.Chem. 285 10786.

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Keywords: SJ 172550, disrupts, p53, MDMX, interaction, inhibitors, SJ172550

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