Cat. No. 3913
Chemical Name: 4-(7,8,9,10-Tetrahydro-7,7,10,10-tetramethylbenzo[b]naphtho[2,3-f][1,4]thiazepin-12-yl-benzoic acid
Biological ActivityRXR agonist. Acts as a retinoid synergist; enhances the potency of AM 80 (Cat. No. 3507) in a HL-60 cell differentiation assay.
Licensing InformationSold under licence.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Umemiya et al (1997) Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J.Med.Chem. 40 4222. PMID: 9435893.
Ohashi et al (2002) Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines. J.Vet.Med.Sci. 64 169. PMID: 11913557.
Ishida et al (2003) Clinically potential subclasses of retinoid synergists revealed by gene expression profiling. Mol.Cancer Ther. 2 49. PMID: 12533672.
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Keywords: HX 630, supplier, HX630, synergists, retinoids, retinoic, pan-RXR, agonists, retinoid, synergist
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