Cat. No. 4041
Chemical Name: N-[2-(2-Furanyl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-N'-(4-methoxyphenyl)urea
Biological ActivityPotent adenosine A3 receptor competitive antagonist. Selective for human A3 receptors over human A1 and A2A receptors (Ki values are 0.29, 141 and 1197 nM respectively). Potently inhibits agonist-induced cyclic AMP elevation in resting T lymphocytes (IC50 = 5 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Baraldi et al (1999) Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. J.Med.Chem. 42 4473. PMID: 10579811.
Gessi et al (2004) Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol.Pharmacol. 65 711. PMID: 14978250.
Varani et al (2010) Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes. Br.J.Pharmacol. 160 101. PMID: 20331607.
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Keywords: MRE 3008F20, supplier, adenosine, A3, receptors, potent, selective, competitive, antagonists, A3AR, MRE3008F20, hA3
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