Rotigotine hydrochlorideCat No.
3896
|
Price and Availability |
|
Alternative Name: N 0923 Chemical Name: (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]am ino]-1-naphthalenol hydrochloride |
|
Biological Activity
Dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Also has significant affinity for 5-HT1A and adrenergic α2B receptors. Exhibits antiparkinsonian acitivity.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Belluzzi et al (2004) N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease. Mov.disord. 9 147. Scheller et al (2009) The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn.Schmiedebergs.Arch.Pharmacol. 379 73.If you know of a useful citation for this product please let us know.
Keywords: Rotigotine hydrochloride, D2, D3, dopamine, agonists, receptor, N0923, parkinson's
Buy Now / Print Quote
Find multiple products by catalog number
Print Quote Facility
Order via your purchasing department
It's now even easier to place orders via your purchasing department.
Simply add a product to your cart & click on the "Print Quote" button.
Neurobiology of Parkinson's Disease
Written by A. Schapira
'Neurobiology and Therapeutics of Parkinson's Disease' highlights the neurobiology of Parkinson's disease and highlights current and novel therapeutic interventions.
GPCRs and Signalling Networks
Written by M.J. Marinissen
'G-Protein-coupled Receptors and Signalling Networks' summarizes the intricate network of intracellular signalling pathways involved in GPCR function.
7-TM Receptor Signalling
Written by T. Kenakin et al
'Seven Transmembrane Receptor Signalling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy
Antidepressants - Current and Future Targets
Written by P. Skolnich et al
'Antidepressants - Current and Future Targets' provides an overview of the current and future targets for the treatment of major depressive disorder.
New Products in this Area
Selective D4 receptor ligand
GSK 789472 hydrochlorideD3 antagonist. Also D2 partial agonist
Rotigotine hydrochlorideDopamine D2/D3 agonist
Careers at Tocris
Tocris Bioscience currently has opportunities for a Chemistry Technician.
If you would like to be considered for any positions not currently advertised, we welcome your speculative application.
