Cat. No. 3896
Alternative Name: N 0923
Chemical Name: (6S)-5,6,7,8-Tetrahydro-6-[propyl[2
Biological ActivityDopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Also has significant affinity for 5-HT1A and adrenergic α2B receptors. Exhibits antiparkinsonian acitivity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Belluzzi et al (2004) N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease. Mov.Disord. 9 147.
Scheller et al (2009) The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn.Schmiedebergs.Arch.Pharmacol. 379 73. PMID: 18704368.
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Keywords: Rotigotine hydrochloride, supplier, D2, D3, dopamine, agonists, receptor, N0923, parkinson's, parkinsons, D2 Receptor Agonists
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High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
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