R&D Systems Inc. Tocris Bioscience Boston Biochem

Rotigotine hydrochloride

Cat. No. 3896

Rotigotine hydrochloride C19H25NOS.HCl [125572-93-2]

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Alternative Name: N 0923

Chemical Name: (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride

Biological Activity

Dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Also has significant affinity for 5-HT1A and adrenergic α2B receptors. Exhibits antiparkinsonian acitivity.

Technical Data

M.Wt:
351.93
Formula:
C19H25NOS.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
125572-93-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Belluzzi et al (2004) N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease. Mov.Disord. 9 147.

Scheller et al (2009) The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn.Schmiedebergs.Arch.Pharmacol. 379 73. PMID: 18704368.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Rotigotine hydrochloride, supplier, D2, D3, dopamine, agonists, receptor, N0923, parkinson's, parkinsons

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