VU 590 dihydrochloride
Cat. No. 3891
Chemical Name: 7,13-Bis[(4-nitrophenyl)methyl]-1,4
Biological ActivityInhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Lewis et al (2009) High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol.Pharmacol. 76 1094. PMID: 19706730.
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Keywords: VU 590 dihydrochloride, supplier, Inhibitor, inhibitors, ROMK, Kir7.1, ion, channel, blocker, blocks, permeability, VU590, dihydrochloride, renal, outer, medullary, potassium, inward, rectifying, K+, channels, Kir1.1
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