VU 590 dihydrochloride
Cat. No. 3891
Chemical Name: 7,13-Bis[(4-nitrophenyl)methyl]-1,4
Biological ActivityInhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Lewis et al (2009) High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol.Pharmacol. 76 1094. PMID: 19706730.
If you know of a relevant citation for this product please let us know.
Keywords: VU 590 dihydrochloride, supplier, Inhibitor, inhibitors, ROMK, Kir7.1, ion, channel, blocker, blocks, permeability, VU590, dihydrochloride, renal, outer, medullary, potassium, inward, rectifying, K+, channels, Kir1.1
Find multiple products by catalog number
New Products in this Area
Positive channel modulator; exerts subtype-specific effectsML 277
Selective Kv7.1 (KCNQ1) potassium channel activator; augments IKs currentNS 11021
Activator of BKCa (KCa1.1) channels
June 28 - July 3, 2014