VU 590 dihydrochloride

Cat. No. 3891

VU 590 dihydrochloride C24H32N4O7.2HCl [313505-85-0]

Price and Availability

For VU 590 dihydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride

Biological Activity

Inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.

Technical Data

M.Wt:
561.46
Formula:
C24H32N4O7.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
313505-85-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Lewis et al (2009) High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol.Pharmacol. 76 1094. PMID: 19706730.

If you know of a relevant citation for this product please let us know.

Keywords: VU 590 dihydrochloride, supplier, Inhibitor, inhibitors, ROMK, Kir7.1, ion, channel, blocker, blocks, permeability, VU590, dihydrochloride, renal, outer, medullary, potassium, inward, rectifying, K+, channels, Kir1.1

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Guide

Highlights over 250 products for cardiovascular research. Request a copy or view PDF today.

divider line

Pain Research Product Guide

Pain Research Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

New Product Guide

NPG

Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

NS 8593 hydrochloride

Selective KCa2 (SK) channel negative modulator; inhibits SK currents

PK-THPP

Potent TASK-3 channel blocker

ML 297

Selective Kir3.1/3.2 (GIRK1/2) channel activator

ML 365

Potent and selective TASK-1 channel blocker

Sign-up for new product e-alerts
divider line

Bio-Techne Events

IBRO 2015

IBRO 2015

July 7 - 11, 2015

Rio de Janeiro, Brazil

Booth: B21