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Licarbazepine

Cat No. 3865

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Alternative Name: GP 47779

Chemical Name: 10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepin-5-carboxa mide

Biological Activity

Active metabolite of oxcarbazepine (Cat. No. 3864). Produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Displays anticonvulsant activity; exhibits minor potentiation of GABA_A receptor currents.

Technical Data

M.Wt:

254.28

Formula:

C₁₅H₁₄N₂O₂

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

[29331-92-8]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Calabresi et al (1995) Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission. Epilepsia 36 990. Benes et al (1999) Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J.Med.Chem. 42 2582. Zheng et al (2009) Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures. Epilepsia 50 83.

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Keywords: Licarbazepine, antiepileptics, anticonvulsants, anticonvulsives, sodium, channels, voltage-gated, Na+, voltage-dependent, inhibitors, inhibits, NaV, GP47779, GP, 47779

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