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CCMI

Cat No. 3837

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Chemical Name: [N-(4-Chlorophenyl)]-a-[(4-chlorophenyl)-aminomethylene ]-3-methyl-5-isoxazoleacetamide

Biological Activity

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC₅ currents (EC₅₀ = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.

Technical Data

M.Wt:

388.25

Formula:

C₁₉H₁₅Cl₂N₃O₂

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Storage:

Store at -20°C

CAS No:

[917837-54-8]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Gronlien et al (2007) Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 72 715. Hu et al (2009) Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. Br.J.Pharmacol. 158 1857. Ng et al (2007) Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABA_A receptor modulators. Proc.Natl.Acad.Sci. 104 8059.

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