TWS 119

Cat No. 3835new product

TWS 119 C18H14N4O2.2CF3CO2H [601514-19-6]

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Chemical Name: 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]o xyphenol ditrifluoroacetate

Biological Activity

Inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).

Technical Data

M.Wt:
546.38
Formula:
C18H14N4O2.2CF3CO2H
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
[601514-19-6]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Ding et al (2003) Synthetic small molecules that control stem cell fate. Proc.Natl.Acad.Sci. 100 7632. Kordes et al (2008) Canonical wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem.Biophys.Res.Comm. 367 116.

If you know of a useful citation for this product please let us know.

View Related Products by Target

Cellular ProcessesGlycogen Synthase Kinase 3Kinases
Stem CellsWnt Signaling

Keywords: TWS 119, TWS119, stem, cells, glycogen, synthase, kinases, gsk-3, gsk3, gsk-3b, gsk-3beta, gsk-3β, inhibitors, neuronal, differentiation

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