TWS 119Cat. No. 3835 |
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Chemical Name: 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenol ditrifluoroacetate |
Biological Activity
Inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).Certificate of Analysis / Safety Data Sheet
References
Ding et al (2003) Synthetic small molecules that control stem cell fate. Proc.Natl.Acad.Sci. 100 7632.
Kordes et al (2008) Canonical wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem.Biophys.Res.Comm. 367 116.
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Keywords: TWS 119, supplier, TWS119, stem, cells, glycogen, synthase, kinases, gsk-3, gsk3, gsk-3b, gsk-3beta, gsk-3β, inhibitors, neuronal, differentiation
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