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MM 11253

Cat. No. 3822

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Chemical Name: 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylic acid

Biological Activity

Selective RARγ antagonist. Blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells.

Technical Data

M.Wt:

462.67

Formula:

C₂₈H₃₀O₂S₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

345952-44-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Holmes et al (2000) Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors. J.Cell.Physiol. 185 61. PMID: 10942519.

Le et al (2000) Modulation of retinoic acid receptor function alters the growth inhibitor response of oral SCC cells to retinoids. Oncogene 19 1457. PMID: 10723137.

Dawson et al (2001) Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity. Cancer Res. 61 4723. PMID: 11406543.

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