R&D Systems Inc. Tocris Bioscience Boston Biochem

Disulfiram

Cat. No. 3807

Disulfiram C10H20N2S4 [97-77-8]

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Alternative Name: Tetraethylthiuram disulfide

Chemical Name: Bis(diethylthiocarbamyoyl)disulfide

Biological Activity

Inhibitor of aldehyde dehydrogenase that displays antialcoholism activity. Shown to reversibly stimulate Ca2+-ATPase activity and inhibit V-ATPase (EC50 = 26 μM). Also inhibits expression of MMP-2 and MMP-9 and displays anti-invasive activity.

Technical Data

M.Wt:
296.54
Formula:
C10H20N2S4
Solubility:
Soluble to 20 mM in DMSO and to 100 mM in ethanol
Storage:
Store at +4°C
CAS No:
97-77-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Starling et al (1996) Stimulation of the Ca2+-ATPase of sarcoplasmic reticulum by disulfiram. Biochem.J. 320 101. PMID: 8947473.

Cho et al (2007) Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. J.Biochem.Mol.Biol. 40 1069. PMID: 18047805.

Johnson et al (2009) Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry. Anal.Biochem. 398 203. PMID: 20018164.

Fisher et al (2010) The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo. J.Pharmacol.Exp.Ther. 332 326. PMID: 19820208.

If you know of a relevant citation for this product please let us know.

Keywords: Disulfiram, supplier, aldehyde, dehydrogenase, inhibitors, anti-alcoholism, stimulates, stimulators, reversible, ca2+-atpase, V-atpase, vacuolar, atpase, MMP, matrix, metalloproteinase, metalloprotease, MMP-2, MMP-9, proteinase, protease

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