Cat. No. 3800
Chemical Name: 4-[6-[(2-Methoxyethoxy)methoxy]-7-t
Biological ActivitySelective RARβγ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Blocks retinoic acid-induced apoptosis ex vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Szondy et al (1997) Induction of apoptosis by retinoids and retinoic acid receptor γ-selective compounds in mouse thymocytes through a novel apoptosis pathway. Mol.Pharmacol. 51 972. PMID: 9187263.
Meister et al (1998) Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectivity binding retinoids in neuroblastoma. Anticancer Res. 18 1777. PMID: 9673404.
Kim et al (2000) The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J.Invest.Dermatol. 114 349. PMID: 10651997.
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Keywords: CD 2665, supplier, CD2665, selective, retinoic, acid, receptors, gamma, beta, RARgamma, RARbeta, RARb, RARg, RARγ, RAR#946;, antagonists