Cat. No. 3793
Chemical Name: 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
Biological ActivityHigh affinity retinol-binding protein 4 (RBP4) ligand (Ki = 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious as fenretinide (Cat. No. 1396) in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR complexes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Manolescu et al (2009) All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases insulin sensitivity in diabetic mice. J.Nutr. 140 311. PMID: 20032483.
Motani et al (2009) Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J.Biol.Chem. 284 7673. PMID: 19147488.
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Keywords: A 1120, supplier, A1120, non-retinoid, retinol-binding, proteins, 4, RBP4, ligands, adipokines
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