Cat. No. 3775
Chemical Name: (S)-3-(Aminomethyl)-5-methylhexanoic acid
Biological ActivityAnticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Field et al (2001) Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. Br.J.Pharmacol. 132 1. PMID: 11156553.
Arain (2009) Pregabalin in the management of partial epilepsy. Neuropsych.Dis.Treat. 5 407.
Kumar et al (2010) Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. J.Neurochem. 113 552. PMID: 20132471.
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Keywords: Pregabalin, supplier, anticonvulsants, neuropathic, pain, GABA, analgesics, anxiolytics, a2d, alpha2delta, α2δ, voltage-sensitive, calcium, channels, Ca2+
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