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Pregabalin

Cat. No. 3775

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Chemical Name: (S)-3-(Aminomethyl)-5-methylhexanoic acid

Biological Activity

Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α₂δ subunit of voltage-sensitive Ca²⁺ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:

159.23

Formula:

C₈H₁₇NO₂

Solubility:

Soluble to 100 mM in water

Storage:

Store at RT

CAS No:

148553-50-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Field et al (2001) Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. Br.J.Pharmacol. 132 1. PMID: 11156553.

Arain (2009) Pregabalin in the management of partial epilepsy. Neuropsych.Dis.Treat. 5 407.

Kumar et al (2010) Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. J.Neurochem. 113 552. PMID: 20132471.

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Keywords: Pregabalin, supplier, anticonvulsants, neuropathic, pain, GABA, analgesics, anxiolytics, a2d, alpha2delta, α2δ, voltage-sensitive, calcium, channels, Ca2+

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