Ceftriaxone disodium salt

Cat. No. 3732

Ceftriaxone disodium salt C18H16N8Na2O7S3 [74578-69-1]

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Chemical Name: 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt

Biological Activity

β-lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.

Technical Data

Soluble to 50 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Rothstein et al (2005) β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433 73. PMID: 15635412.

Lipski et al (2007) Neuroprotective potential of ceftriaxone in in vitro models of stroke. Neuroscience 146 617. PMID: 17363173.

Rawls et al (2007) The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Br.J.Pharmacol. 151 1095. PMID: 17592517.

If you know of a relevant citation for this product please let us know.

Keywords: Ceftriaxone disodium salt, supplier, GLT-1, EAAT2, glutamate, transporters, activators, expression, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitter, antibiotics

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