Ceftriaxone disodium salt
Cat. No. 3732
Chemical Name: 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt
Biological Activityβ-lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Rothstein et al (2005) β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433 73. PMID: 15635412.
Lipski et al (2007) Neuroprotective potential of ceftriaxone in in vitro models of stroke. Neuroscience 146 617. PMID: 17363173.
Rawls et al (2007) The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Br.J.Pharmacol. 151 1095. PMID: 17592517.
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Keywords: Ceftriaxone disodium salt, supplier, GLT-1, EAAT2, glutamate, transporters, activators, expression, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitter, antibiotics
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