R&D Systems Inc. Tocris Bioscience Boston Biochem

Pristimerin

Cat. No. 3731

Pristimerin C30H40O4 [1258-84-0]

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Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid methyl ester

Biological Activity

Potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM). Also suppresses NF-κB activation via inhibition of proteasome chymotrypsin-like activity and IKKαβ. Displays antitumor, anti-inflammatory and antimicrobial activities.

Technical Data

M.Wt:
464.64
Formula:
C30H40O4
Solubility:
Soluble to 25 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
1258-84-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Byun et al (2009) Reactive oxygen species-dependent activation of Bax and Poly(ADP)-ribose) polymerase-1 is requried for mitochondrial cell death induced by triterpenoid Pristimerin in human cervical cancer cells. Mol.Pharmacol. 76 734. PMID: 19574249.

King et al (2009) Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem.Biol. 16 1045. PMID: 19875078.

Tiedemann et al (2009) Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo. Blood 113 4027. PMID: 19096011.

If you know of a relevant citation for this product please let us know.

Keywords: Pristimerin, supplier, MAGL, MGL, monoacylglycerol, lipase, inhibitors, lipases, NF-kB, NF-kappaB, NF-κB, inhibits, suppresses, activation, nuclear, factor, kappa, B, transcription, factors

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