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Boc-MLF

Cat. No. 3730

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Biological Activity

Antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC₅₀ of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis.

Technical Data

M.Wt:

509.66

C₂₅H₃₉N₃O₆S

Boc-MLF

Soluble in DMSO

Store at -20°C

67247-12-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Boxio et al (2005) The immunostimulatory peptide WKYMVm-NH₂ activates bone marrow mouse neutrophils via multiple signal transduction pathways. Scand.J.Immunol. 62 140. PMID: 16101820.

Karlsson et al (2005) Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol. 78 762.

Stenfeldt et al (2007) Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation 30 224. PMID: 17687636.

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Keywords: Boc-MLF, supplier, formyl, peptide, receptor, 1, fMLF, FPR1, antagonists

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7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy