R&D Systems Inc. Tocris Bioscience Boston Biochem

VU 0255035

Cat. No. 3727

VU 0255035 C18H20N6O3S2 [1135243-19-4]

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Chemical Name: N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide

Biological Activity

Highly selective muscarinic M1 antagonist (Ki = 14.87 nM). Targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.

Technical Data

M.Wt:
432.52
Formula:
C18H20N6O3S2
Solubility:
Soluble to 20 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
1135243-19-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Sheffler et al (2009) A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol.Pharmacol. 76 356. PMID: 19407080.

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Keywords: VU 0255035, supplier, selective, muscarinic, receptors, M1, antagonists, mAChR, acetylcholine, ACh, VU0255035

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