Cat. No. 3727
Chemical Name: N-[3-Oxo-3-[4-(4-pyridinyl)-1-piper
Biological ActivityHighly selective muscarinic M1 antagonist (Ki = 14.87 nM). Targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Sheffler et al (2009) A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol.Pharmacol. 76 356. PMID: 19407080.
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Keywords: VU 0255035, supplier, selective, muscarinic, receptors, M1, antagonists, mAChR, acetylcholine, ACh, VU0255035
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June 30 - July 2, 2014
Booth Number: 39