R&D Systems Inc. Tocris Bioscience Boston Biochem

Cryptotanshinone

Cat. No. 3713

Cryptotanshinone C19H20O3 [35825-57-1]

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Chemical Name: 1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl[1,2-b]furan-10,11-dione

Biological Activity

Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC50 = 4.6 μM). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC50 = 4.09 μM) and reduction in Aβ peptide generation.

Technical Data

M.Wt:
296.36
Formula:
C19H20O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
35825-57-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Kim et al (2007) Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Mol.Pharmacol. 72 62. PMID: 17429005.

Shin et al (2009) Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 69 193. PMID: 19118003.

Wong et al (2009) Cryptotanshinone, an acetylcholinesterase inhibitor from Salivia miltiorrhiza, ameliorates scopolamine-induced amnesia in morris water maze task. Planta Med. 76 288.

Zhang et al (2009) Cryptotanshinone, a compound from Saliva miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro. Neurosci.Letts. 452 90.

If you know of a relevant citation for this product please let us know.

Keywords: Cryptotanshinone, supplier, acetylcholinesterases, inhibitors, Abeta, amyloid-beta, beta-amyloid, b-amyloid, AMP-activated, protein, kinases, AMPK, STAT3, signal, transducers, activators, transcription, factors, β-amyloid

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