Cat. No. 3710
Alternative Name: APR-246
Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)
Biological ActivityMethylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Bykov et al (2005) PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis. Oncogene 24 3484. PMID: 15735745.
Shen et al (2008) PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene 27 6571. PMID: 18663359.
Stuber et al (2009) PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein. Mol.Cancer 8 23. PMID: 19323829.
If you know of a relevant citation for this product please let us know.
Keywords: PRIMA-1MET, supplier, Restores, mutant, p53, activity, transcription, factors, APR-246
Find multiple products by catalog number
New Products in this Area
Stabilizes G-quadruplexes; inducing DNA damage and cell cycle arrestSCH 529074
Restores mutant p53 activity
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.