R&D Systems Inc. Tocris Bioscience Boston Biochem

PRIMA-1MET

Cat. No. 3710

PRIMA-1MET C10H17NO3 [5291-32-7]

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Alternative Name: APR-246

Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

Biological Activity

Methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.

Technical Data

M.Wt:
199.25
Formula:
C10H17NO3
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
5291-32-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Bykov et al (2005) PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis. Oncogene 24 3484. PMID: 15735745.

Shen et al (2008) PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene 27 6571. PMID: 18663359.

Stuber et al (2009) PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein. Mol.Cancer 8 23. PMID: 19323829.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: PRIMA-1MET, supplier, Restores, mutant, p53, activity, transcription, factors, APR-246

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