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Scrambled ¹⁰Panx

Cat No. 3708

Scrambled 10Panx Phe-Ser-Val-Tyr-Trp-Ala-Gln-Ala-Asp-Arg

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Alternative Name: ^scpanx

Biological Activity

Scrambled version of ¹⁰Panx (Cat.No. 3348), a Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions, inhibits P2X₇-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. ¹⁰Panx also blocks activation of NMDA receptor secondary currents (I_2nd) by > 70%.

Technical Data

M.Wt:

1242.37

Formula:

C₅₈H₇₉N₁₅O₁₆

Sequence:

FSVYWAQADR

Storage:

Store at -20°C

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Pelegrin and Surprenant (2006) Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X₇ receptor. EMBO J. 25 5071. Wang et al (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 293 C1112. Thompson et al (2008) Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 322 1555.

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Keywords: Scrambled 10Panx, Panx-1, mimetic, inhibitory, peptide, blocks, pannexin-1, gap, junctions, Connexins, Channels, modulators

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