VU 0361737

Cat. No. 3707

VU 0361737 C13H11ClN2O2 [1161205-04-4]

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Chemical Name: N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide

Biological Activity

Selective positive allosteric modulator at mGlu4 receptors (EC50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. Brain penetrant.

Technical Data

M.Wt:
262.69
Formula:
C13H11ClN2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
1161205-04-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Engers et al (2009) Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J.Med.Chem. 52 4115. PMID: 19469556.

Engers et al (2011) Discovery, synthesis, and structure-activity relationship development of a series of N-(4-Acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats. J.Med.Chem. 54 1106. PMID: 21247167.

If you know of a relevant citation for this product please let us know.

Keywords: VU 0361737, supplier, Selective, positive, allosteric, modulators, mGlu4, mGluR4, group, III, metabotropic, glutamate, receptors, VU0361737

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