Cat. No. 3707
Chemical Name: N-(4-Chloro-3-methoxyphenyl)-2-pyri
Biological ActivitySelective positive allosteric modulator at mGlu4 receptors (EC50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Engers et al (2009) Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J.Med.Chem. 52 4115. PMID: 19469556.
Engers et al (2011) Discovery, synthesis, and structure-activity relationship development of a series of N-(4-Acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats. J.Med.Chem. 54 1106. PMID: 21247167.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: VU 0361737, supplier, Selective, positive, allosteric, modulators, mGlu4, mGluR4, group, III, metabotropic, glutamate, receptors, VU0361737, Glutamate (Metabotropic) Group III Receptor Modulators
Find multiple products by catalog number
New Products in this Area
Potent and selective negative allosteric modulator at mGlu5ABP 688
High affinity human mGlu5 receptor antagonistVU 0469650 hydrochloride
Potent and selective negative allosteric modulator of mGlu1VU 0422288
Selective group III mGlu positive allosteric modulator
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.