Cat. No. 3707
Chemical Name: N-(4-Chloro-3-methoxyphenyl)-2-pyri
Biological ActivitySelective positive allosteric modulator at mGlu4 receptors (EC50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. Brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Engers et al (2009) Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J.Med.Chem. 52 4115. PMID: 19469556.
Engers et al (2011) Discovery, synthesis, and structure-activity relationship development of a series of N-(4-Acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats. J.Med.Chem. 54 1106. PMID: 21247167.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: VU 0361737, supplier, Selective, positive, allosteric, modulators, mGlu4, mGluR4, group, III, metabotropic, glutamate, receptors, VU0361737
Find multiple products by catalog number
New Products in this Area
Selective negative allosteric modulator at mGlu3ML 337
Selective negative allosteric modulator of mGlu3LY 379268 disodium salt
Sodium salt of LY 379268 (Cat. No. 2453); selective group II mGlu receptor agonistCPPHA
Positive allosteric modulator at mGlu1 and mGlu5
Win a Kindle
March 18 - 21, 2014
University of Regensburg, Germany
Booth Number: 44