R&D Systems Inc. Tocris Bioscience Boston Biochem

DPN

Cat. No. 1494

DPN C15H13NO2 [1428-67-7]

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Alternative Name: Diarylpropionitrile

Chemical Name: 2,3-bis(4-Hydroxyphenyl)-propionitrile

Biological Activity

Highly potent estrogen ERβ receptor agonist with a 70-fold selectivity over ERα (EC50 values are 0.85 and 66 nM respectively). Relaxes mesenteric arteries in vitro. Shown to regulate expression of GluR1, GluR2 and GluR3 in rat hippocampus.

Technical Data

M.Wt:
239.27
Formula:
C15H13NO2
Solubility:
Soluble to 30 mM in 1eq. NaOH and to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
1428-67-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Meyers et al (2001) Estrogen receptor-β potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J.Med.Chem. 44 4230. PMID: 11708925.

Harrington et al (2003) Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol.Cell.Endocrinol. 206 13. PMID: 12943986.

Montgomery et al (2003) Acute effects of oestrogen receptor subtype-specific agonists on vascular contractility. Br.J.Pharmacol. 139 1249. PMID: 12890703.

Waters et al (2009) Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus. Brain Res. 1290 1. PMID: 19596275.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: DPN, supplier, potent, ERβ, ERbeta, agonists, ERb, ERR, Estrogen, Receptors

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