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N-NonyldeoxynojirimycinCat. No. 3691 |
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Alternative Name: NN-DNJ Chemical Name: (2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol |
Biological Activity
Glucosidase inhibitor (IC50 values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
References
Sawkar et al (2002) Chemical chaperones increase the cellular activity of N307S β-glucosidase: a therapeutic strategy for Gaucher disease. Proc.Natl.Acad.Sci.USA 99 15428.
Andersson et al (2004) Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem.Pharmacol. 67 697. PMID: 14757169.
Mellor et al (2004) Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem.J. 381 867. PMID: 15128289.
If you know of a relevant citation for this product please let us know.
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Keywords: N-Nonyldeoxynojirimycin, supplier, Glucosidase, inhibitors, acid, α-glucosidase, alpha-glucosidase, GAA, α-1, 6-glucosidase, alpha-1, 6-glucosidaset, a-glucosidase, glycosylases, chemical, chaperone, NNDNJ
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