DMAT

Cat No. 3686new product

DMAT C9H7Br4N3

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Chemical Name: 2-(Dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidazole

Biological Activity

High affinity, cell-permeable inhibitor of casein kinase 2 (CK2) (Ki = 40 nM; IC50 = 0.13 μM). Displays no activity at CK1 at concentrations up to 200 μM. Also inhibits Pim kinase (IC50 values are 0.097, 0.148 and 1.6 μM for Pim-3, Pim-1 and Pim-2 kinase respectively), and protein kinase D1 (IC50 = 0.18 μM). Derivative of TBB (Cat.No. 2275).

Technical Data

M.Wt:
476.79
Formula:
C9H7Br4N3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Pagano et al (2004) 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2. Biochem.Biophys.Res.Comm. 321 1040. Inglis et al (2008) Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J.Biol.Chem. 284 2598. Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353.

If you know of a useful citation for this product please let us know.

View Related Products by Target

Casein Kinase 2Kinases
Pim KinaseProtein Kinase D

Keywords: DMAT, cell-permeable, kinase, inhibitors, casein, kinase, 2, CK2, pim, kinase, pim1, pim2, pim3, protein, kinase, d1, pkd1

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