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NPY 5RA972

Cat. No. 3677

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Chemical Name: N-[4-Methyl-9-(1-methylethyl)-9H-carbazol-3-yl]-4-morpholinecarboxamide

Biological Activity

Potent and selective neuropeptide Y Y₅ receptor antagonist (IC₅₀ values are 3.1, >10000, >10000 and >10000 nM for Y₅, Y₁, Y₂ and Y₄ receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant.

Technical Data

M.Wt:

351.44

Formula:

C₂₁H₂₅N₃O₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

439861-56-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Block et al (2002) Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. J.Med.Chem. 45 3509. PMID: 12139462.

Turnbull et al (2002) Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes 51 2441. PMID: 12145156.

Morris et al (2007) Neuropeptide Y suppresses absence seizures in a genetic model primarily through effects on Y receptors. Eur.J.Neurosci. 25 1136. PMID: 17331209.

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Keywords: NPY 5RA972, supplier, NPY5RA972, neuropeptide, Y, Y5, receptors, antagonists, potent, selective, NPYY5, neuropeptides

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