PF 514273Cat No. 3676 |
Price and Availability |
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Chemical Name: 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropr opyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H) -one |
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Biological Activity
Potent and selective CB1 receptor antagonist (Ki values are 1 and > 10000 nM at CB1 and CB2 receptors respectively). Inhibits food intake in vivo following oral administration.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Dow et al (2009) Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazole[3,4-f][1,4]oxazepin-8-(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. J.Med.Chem. 52 2652.If you know of a useful citation for this product please let us know.
Keywords: PF 514273, Potent, and, selective, CB1, agonists, cannabinoids, Receptors, PF514273, cb1r
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