R&D Systems Inc. Tocris Bioscience Boston Biochem

TMCB

Cat. No. 3675

TMCB C11H9Br4N3O2 [905105-89-7]

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Chemical Name: 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid

Biological Activity

Dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki values are 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2 respectively).

Technical Data

M.Wt:
534.82
Formula:
C11H9Br4N3O2
Solubility:
Soluble to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
905105-89-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353. PMID: 18588507.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: TMCB, supplier, casein, kinase, 2, ck2, extracellular-signal-regulated, kinase, 8, ERK8, dual, kinase, inhibitors

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