Cat. No. 3675
Chemical Name: 2-(4,5,6,7-Tetrabromo-2-(dimethylam
Biological ActivityDual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki values are 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2 respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353. PMID: 18588507.
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Keywords: TMCB, supplier, casein, kinase, 2, ck2, extracellular-signal-regulated, kinase, 8, ERK8, dual, kinase, inhibitors
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