R&D Systems Inc. Tocris Bioscience Boston Biochem

TMCB

Cat. No. 3675

TMCB C11H9Br4N3O2 [905105-89-7]

Price and Availability

For TMCB pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2-(4,5,6,7-Tetrabromo-2-(dimethylam­ino)-1H-benzo[d]imidazol-1-yl)acetic acid

Biological Activity

Dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki values are 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2 respectively).

Technical Data

M.Wt:
534.82
Formula:
C11H9Br4N3O2
Solubility:
Soluble to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
905105-89-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353. PMID: 18588507.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Casein Kinase 2 ERK
Kinases MAPK

Keywords: TMCB, supplier, casein, kinase, 2, ck2, extracellular-signal-regulated, kinase, 8, ERK8, dual, kinase, inhibitors

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Guide

Request your free copy

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Some of the most potent
kinase inhibitors all on one plate

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

New Product Guide

NPG

Highlights over 130 new products added in 2012. Request a copy or view PDF today.

divider line

New Products in this Area

Flavopiridol hydrochloride

Cyclin-dependent kinase inhibitor

GSK2578215A

Potent, selective LRRK2 inhibitor; brain penetrant

Amlexanox

Inhibitor of TBK1 and IKKε; antiallergic agent

PF 05212384

Potent and selective dual PI 3-kinase/mTOR inhibitor

PF 03814735

Aurora kinase A and B inhibitor

PF 04691502

Dual PI 3-K/mTOR inhibitor

TNP

Inhibitor of IP6K; also inhibits IP3K

ACHP

Selective IKKα and IKKβ inhibitor

PD 0332991 isethionate

Potent, selective Cdk4/6 inhibitor; brain penetrant

CZC 24832

Selective inhibitor of PI 3-Kinase γ

LY 333531 hydrochloride

Protein kinase C inhibitor; selective for β isozymes

PF 06465469

Potent inhibitor of interleukin-2 inducible T cell kinase (ITK). Also inhibits BTK

10Z-Hymenialdisine

Pan kinase inhibitor; potently inhibits MEK-1

CP 690550 citrate

Potent JAK inhibitor

WYE 687 dihydrochloride

Potent and selective mTOR inhibitor

N,N-Dimethylsphingosine

Sphingosine kinase inhibitor

PEP 005

Protein kinase C activator

CZC 54252 hydrochloride

Potent LRRK2 inhibitor; neuroprotective

Bisindolylmaleimide II

Potent PKC inhibitor and nicotinic receptor antagonist

CID 2011756

Pan protein kinase D (PKD) inhibitor; cell permeable

Sign-up for new product e-alerts
divider line

20% Discount*

Potent, selective LRRK2 inhibitor

Potent LRRK2 inhibitor now available from Tocris Bioscience

Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.

* Terms & conditions