R&D Systems Inc. Tocris Bioscience Boston Biochem

Donitriptan hydrochloride

Cat. No. 3665

Donitriptan hydrochloride C23H25N5O2.HCl [170912-52-4]

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Chemical Name: 1-[[[3-(2-Aminoethyl)-1H-indol-5-yl­]oxy]acetyl]-4-(4-cyanophenyl)-piperazine hydrochloride

Biological Activity

Brain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively). Inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Displays antimigraine activity.

Technical Data

M.Wt:
439.94
Formula:
C23H25N5O2.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
170912-52-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Letienne et al (2003) Donitriptan selectively decreases jugular venous oxygen saturation in the anesthetized pig: further insights into its mechanism of action relevant to headache relief. J.Pharmacol.Exp.Ther. 305 749. PMID: 12606602.

Letienne et al (2005) Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: an overlooked mechanism of antimigraine action? J.Pharmacol.Exp.Ther. 315 849. PMID: 16027226.

Munoz-Islas et al (2006) Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilation via 5-HT1B rather than 5-HT1D receptors. Br.J.Pharmacol. 149 82. PMID: 16880765.

If you know of a relevant citation for this product please let us know.

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