NXY 059

Cat No. 3645

NXY 059 C11H13NNa2O7S2 [168021-79-2]

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Chemical Name: 4-[[(1,1-Dimethylethyl)oxoimino]methyl]-1,3-benzenedisu lfonic acid disodium salt

Biological Activity

Free radical trapping agent. Reduces infarct size and preserves brain function in several animal models of acute ischemic stroke. Neuroprotectant.

Technical Data

M.Wt:
381.33
Formula:
C11H13NNa2O7S2
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
[168021-79-2]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Peeling et al (2001) Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke. Neuropharmacology 40 433. Sydserff et al (2002) Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window. Br.J.Pharmacol. 135 103. Culot et al (2009) Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study. Brain Res. 1294 144.

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Miscellaneous Compounds

Keywords: NXY 059, Free, radical, trapping, agent, neuroprotectant, scavenger, NXY059

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