Src I1Cat No. 3642 |
Price and Availability |
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Chemical Name: 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine |
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Biological Activity
Potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50 values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC50 values are 0.32 and 30 μM respectively). Can be used in parallel with PP 1 and PP 2 to inhibit Src family kinases.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Tian et al (2001) Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines. Biochem. 40 7084. Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem.J. 408 297.If you know of a useful citation for this product please let us know.
Keywords: Src I1, Dual, site, Src, kinases, inhibitors, Lck, family
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