R&D Systems Inc. Tocris Bioscience Boston Biochem

JWH 018

Cat. No. 1342

JWH 018 C24H23NO [209414-07-3]

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Chemical Name: (1-Pentyl-1H-indol-3-yl)-1-naphthal­enylmethanone

Biological Activity

Potent cannabinoid receptor agonist with mild selectivity for CB2 (Ki values are 2.94 and 9.0 nM for CB2 and CB1 receptors respectively).

Technical Data

M.Wt:
341.45
Formula:
C24H23NO
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
209414-07-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Chin et al (1999) The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor. J.Pharmacol.Exp.Ther. 291 837. PMID: 10525107.

Aung et al (2000) Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend. 60 133. PMID: 10940540.

Huffman et al (2003) 3-Indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor. Bioorg.Med.Chem. 11 539. PMID: 12538019.

If you know of a relevant citation for this product please let us know.

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