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JWH 018

Cat. No. 1342

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Chemical Name: (1-Pentyl-1H-indol-3-yl)-1-naphthalenylmethanone

Biological Activity

Potent cannabinoid receptor agonist with mild selectivity for CB₂ (K_i values are 2.94 and 9.0 nM for CB₂ and CB₁ receptors respectively).

Technical Data

M.Wt:

341.45

Formula:

C₂₄H₂₃NO

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Desiccate at -20°C

CAS No:

209414-07-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Chin et al (1999) The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor. J.Pharmacol.Exp.Ther. 291 837. PMID: 10525107.

Aung et al (2000) Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding. Drug Alcohol Depend. 60 133. PMID: 10940540.

Huffman et al (2003) 3-Indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB₁ cannabinoid receptor. Bioorg.Med.Chem. 11 539. PMID: 12538019.

If you know of a relevant citation for this product please let us know.

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